The laboratory research plan includes the following major topics:

  • (a) computational transcriptomics for the elucidation of the mechanisms of plant development and revealing the mechanisms of plant-microorganisms evolutionary co-adaptation;
  • (b) computational genomics: de-novo motif discovery for the prediction of transcription factor binding sites (TFBS) and cis-regulatory modules (CRMs) as well as the reconstruction of gene regulatory networks;
  • (c) bioinformatics for non-coding RNAs and mRNA hidden coding potential.

The ultimate goal of these investigations is the discovery of the molecular mechanisms regulating plant morphogenesis, stress tolerance and co-adaptation with other organisms in eco-systems. As an additional output, new mathematical methods and algorithms for the analysis of high-throughput biological data will be developed.

So, directions of lab’s work are the following:

  • Study of morphogenetic mechanisms and their evolution in plants, including:
    (1) study of auxin influence on root development in A.thaliana;
    (2) study of plant hormone action mechanisms using whole genome data analysis;
    (3) study and functional annotation of regulatory DNA motifs using computational analysis of whole genome data;
    (4) study of morphogenetic mechanisms evolution in plants using molecular phylogenetic analysis.
  • Development of computer methods and programs for the whole genome data analysis.
  • Growing the specialists in computational transcriptomics and bioinformatics.