The laboratory research plan includes the following major topics:
- (a) computational transcriptomics for the elucidation of the mechanisms of plant development and revealing the mechanisms of plant-microorganisms evolutionary co-adaptation;
- (b) computational genomics: de-novo motif discovery for the prediction of transcription factor binding sites (TFBS) and cis-regulatory modules (CRMs) as well as the reconstruction of gene regulatory networks;
- (c) bioinformatics for non-coding RNAs and mRNA hidden coding potential.
The ultimate goal of these investigations is the discovery of the molecular mechanisms regulating plant morphogenesis, stress tolerance and co-adaptation with other organisms in eco-systems. As an additional output, new mathematical methods and algorithms for the analysis of high-throughput biological data will be developed.
So, directions of lab’s work are the following:
- Study of morphogenetic mechanisms and their evolution in plants, including:
(1) study of auxin influence on root development in A.thaliana;
(2) study of plant hormone action mechanisms using whole genome data analysis;
(3) study and functional annotation of regulatory DNA motifs using computational analysis of whole genome data;
(4) study of morphogenetic mechanisms evolution in plants using molecular phylogenetic analysis.
- Development of computer methods and programs for the whole genome data analysis.
- Growing the specialists in computational transcriptomics and bioinformatics.